preparation and characterization of rifampin loaded mesoporous silica nanoparticles as a potential system for pulmonary drug delivery
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abstract
the goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. the mesoporous silica nanoparticles were prepared by using tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant); the prepared nanoparticles were characterized in terms of their particle size measurement and porosimetry. the results showed that the particle size is 218±46 nm (mean± sd) and surface area is 816 m2g-1 . in order to load rifampin within the mesopores, adsorption experiments using three different solvents (methanol, water and dimethyl sulfoxide) were carried out. the loading procedure results in a significant improvement of the amount of rifampin loaded into mesoporous silica nanoparticles and methanol was found to be a suitable solvent providing a drug entrapment efficiency of 52 %. rifampin loaded nanoparticles underwent different in-vitro tests including: sem and drug release. the in vitro drug release was investigated with buffer phosphate (ph=7.4). regarding the drug release study a biphasic pattern of release was observed. the drug-loaded mesoporous silica nanoparticles was capable of releasing 100% drug content after 24h following a burst effect in the first four hours. the prepared rifampin loaded nanoparticles seem to have potential for use in a pulmonary drug delivery.
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Journal title:
iranian journal of pharmaceutical researchجلد ۱۴، شماره ۱، صفحات ۲۷-۳۴
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